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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...
Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...

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Related Experiment Video

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Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
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Published on: March 4, 2014

Neuroplasticity of the sensorimotor cortex during learning.

Joseph Thachil Francis1, Weiguo Song

  • 1Department of Physiology, The Robert F. Furchgott Center of Neural and Behavioral Science, and the Joint Program in Biomedical Engineering at SUNY Downstate and NUY-POLY, State University of New York (SUNY) Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. joey199us@gmail.com

Neural Plasticity
|September 28, 2011
PubMed
Summary

Investigating sensorimotor cortex plasticity in rats, this study explores protein kinase Mζ (PKMζ) inhibition

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Last Updated: May 29, 2026

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Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

Area of Science:

  • Neuroscience
  • Motor Control
  • Synaptic Plasticity

Background:

  • Sensorimotor (SM) cortex plasticity is crucial for motor learning and recovery.
  • Understanding the molecular mechanisms, particularly involving long-term potentiation (LTP), is essential.
  • Protein kinase Mζ (PKMζ) is implicated in maintaining LTP.

Purpose of the Study:

  • To discuss current challenges in understanding SM cortex plasticity.
  • To investigate the role of PKMζ in sensorimotor plasticity using rat models.
  • To explore the potential of modulating PKMζ for therapeutic interventions.

Main Methods:

  • Focus on reaching and grasping movements in rats.
  • Utilizing inhibition and overexpression of PKMζ.
  • Employing brain-machine interface (BMI) paradigms.
  • Analyzing neurophysiological and behavioral data.

Main Results:

  • Preliminary work on PKMζ inhibition and its effects is discussed.
  • The study sets the stage for directly modulating LTP to understand its behavioral and network influences.
  • New analysis techniques for neuroplasticity are introduced.

Conclusions:

  • Direct modulation of LTP via PKMζ offers a novel approach to study sensorimotor plasticity.
  • Understanding PKMζ's role can lead to new therapeutic strategies for motor disorders.
  • Advanced analytical methods are key to deciphering complex neuroplasticity.