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Updated: May 29, 2026

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
Published on: October 6, 2023
[Adaptive hypometabolism in man]
Abstract:
Two hypotheses of functional organization of hypoxic hypometabolism in man is discussed. One is a bioenergetic hypothesis stating that progressive oxygen deficiency in the cells leads to suppression of macrophage production. The other regards hypometabolism as a result of decreased energy consumption in response to hypoxia or the lack of energy of any etiology; it results in impaired intensity of energy metabolism. The letter strategy is underlain by central regulatory mechanisms for which proteins of the HIF-factor system are the most probable markers.
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