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Updated: May 29, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

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Published on: November 8, 2015

Pregnancy under everolimus-based immunosuppression.

Massimiliano Veroux¹, Daniela Corona, Pierfrancesco Veroux

¹Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced technologies, University Hospital of Catania, Catania, Italy. veroux@unict.it

Transplant International : Official Journal of the European Society for Organ Transplantation

|September 29, 2011

Summary

This summary is machine-generated.

This study reports the first successful live birth in a kidney transplant recipient treated with everolimus throughout pregnancy. While promising, pregnancies in everolimus-exposed kidney transplant recipients are considered high-risk.

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Area of Science:

Nephrology
Reproductive Medicine
Pharmacology

Background:

Live birth is a significant success in kidney transplantation.
Pregnancy outcomes are well-documented for calcineurin inhibitors like cyclosporine and tacrolimus.
Limited data exists on pregnancy in kidney transplant recipients (KTRs) using mTOR inhibitors such as sirolimus or everolimus.

Observation:

This case study details the first reported successful delivery in an organ transplant recipient exposed to everolimus during the entire gestation period.
The infant showed no congenital anomalies.
The mother experienced a successful renal outcome post-pregnancy.

Findings:

Successful pregnancy and delivery are possible in KTRs treated with everolimus.
Everolimus exposure during gestation did not result in congenital anomalies in the neonate.
The maternal kidney transplant function remained stable.

Implications:

This case provides crucial evidence for the feasibility of pregnancy in KTRs on everolimus.
It suggests everolimus may be a viable option for KTRs desiring pregnancy, though caution is warranted.
Further research is needed to establish safety profiles and management guidelines for everolimus-exposed pregnancies in KTRs, considering them high-risk.