Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

558
This protocol describes the development of a neonatal piglet model of acute lung injury that models early pathogenic events occurring in the preterm lung, including sub-adequate surfactant quantity, hyperoxia, high-pressure ventilation, and inflammation, to facilitate understanding of molecular triggers of bronchopulmonary dysplasia and enhance therapeutic...
558
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

615
As legislative restrictions change, resulting in increased accessibility of cannabinoid products, it is critically important to develop models to study the impact of these exposures, particularly during pregnancy. A preclinical model of moderate prenatal cannabinoid exposure through voluntary ingestion has been developed, enabling more in-depth...
615
Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit11:50

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

27.5K
Creative music therapy for preterm infants and their parents has emerged as a promising family-integrated early intervention. We present a detailed protocol on how to use vocal interaction, humming, or singing to empower preterm infants and their...
27.5K
Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants07:26

Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants

15.0K
Human umbilical cord (UC) can be obtained during the perinatal period as a result of preterm, term, and postterm delivery. In this protocol, we describe the isolation and characterization of UC-derived mesenchymal stem cells (UC-MSCs) from fetuses/infants at 19-40 weeks of...
15.0K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

12.5K
This manuscript describes the Research Prioritization by Affected Communities (RPAC) protocol and findings from its use with women at risk for preterm birth. Using the protocol, women identified and prioritized their unanswered questions about pregnancy, birth and neonatal care aimed at influencing research priority setting by funders and...
12.5K
Transcutaneous Microcirculatory Imaging in Preterm Neonates06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

8.5K
Microcirculatory imaging (MI) is used to monitor peripheral perfusion in critically ill or preterm neonates. This manuscript and video demonstrates the optimal approach for obtaining high-quality...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parental Anxiety Trajectories 2 Years After NICU Discharge.

Pediatrics·2026
Same author

Association between exposure to stress and experienced discomfort in preterm infants.

Pediatric research·2026
Same author

A Factor Analysis of the COMFORTneo Scale: What Are We Measuring?

Paediatric & neonatal pain·2026
Same author

The role of asymmetrical finger postures during fidgety age in the prediction of unilateral cerebral palsy.

Early human development·2026
Same author

Early regional splanchnic oxygen saturation and the development of necrotizing enterocolitis in preterm infants 28-32 weeks of gestation.

Early human development·2026
Same author

Comparison of early growth and development in very preterm children in the Netherlands between the 1980s and 2000s.

BMC pediatrics·2026

Related Experiment Video

Updated: Jan 20, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

558

Neurodevelopmental outcome in preterm infants.

Arend F Bos1, Elise Roze

  • 1Division of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. a.f.bos@bkk.umcg.nl

Developmental Medicine and Child Neurology
|September 29, 2011
PubMed
Summary

Preterm children show cognitive and motor score distributions shifted leftward compared to norms, indicating developmental delays. Brain lesions and gestational age did not influence these outcomes in this cohort.

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

12.5K
Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.5K

Related Experiment Videos

Last Updated: Jan 20, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

558
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

12.5K
Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.5K

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Child Psychology

Background:

  • Preterm birth is associated with increased risks for neurodevelopmental impairments.
  • Understanding the specific cognitive and motor deficits in very preterm children is crucial for early intervention.

Purpose of the Study:

  • To determine the distribution of cognitive and motor scores in very preterm children at school age.
  • To investigate the influence of brain lesions and decreasing gestational age on these outcomes.

Main Methods:

  • One hundred and six very preterm children (gestational age 24.0-31.6 wk) were assessed between 6 to 12 years.
  • Cognitive function was evaluated using the Wechsler Intelligence Scale for Children (IQ).
  • Motor outcome was assessed with the Movement Assessment Battery for Children (Movement ABC).

Main Results:

  • Cognitive and motor scores were normally distributed but shifted leftward, indicating lower-than-average performance.
  • Mean total IQ was 0.60 SD below norm, with verbal and performance IQs also significantly lower.
  • Movement ABC z-scores were -1.27 SD below norm, indicating motor impairments.

Conclusions:

  • Very preterm children exhibit a leftward shift in cognitive and motor outcome distributions at school age.
  • The observed effect sizes suggest significant developmental disadvantages for preterm individuals.
  • No correlation was found between brain lesions or gestational age and the cognitive/motor scores in this study group.