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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Estimation of left ventricular function using a novel acoustic-based device.

Naira Radzievsky¹, Surik Papyan, Igal Kushnir

¹Deep Breeze Ltd, Or Akiva, Israel.

European Journal of Clinical Investigation

|September 29, 2011

Summary

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A new acoustic device can estimate left ventricular ejection fraction (LVEF), showing significant correlation with echocardiography. This vibration response imaging (VRI) technology may aid in patient triage for LVEF assessment.

Area of Science:

Cardiology
Biomedical Engineering
Medical Devices

Background:

Left ventricular ejection fraction (LVEF) is a critical measure of cardiac function.
Current methods for LVEF assessment, such as echocardiography, require specialized equipment and expertise.
There is a need for accessible and feasible methods to estimate LVEF.

Purpose of the Study:

To evaluate the feasibility of a novel acoustic-based device, vibration response imaging (VRI), for estimating LVEF.
To compare LVEF estimates obtained by VRI (VRI-LVEF) with those from standard echocardiography (echo-LVEF).

Main Methods:

141 subjects (117 patients, 24 healthy volunteers) underwent simultaneous VRI and echocardiography.
VRI recorded low-frequency acoustic signals from the thorax, processed with an algorithm incorporating acoustic, ECG, and clinical data.

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Last Updated: May 29, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

Echocardiography determined LVEF using the biplane Simpson's method.

Main Results:

VRI-LVEF showed significant correlation with echo-LVEF (R² = 0.59, P < 0.001).
VRI accurately predicted reduced (<50%) and severely reduced (<35%) echo-LVEF with high sensitivity and specificity.
Performance metrics included sensitivities of 84% and 82%, specificities of 86% and 91% for reduced and severely reduced LVEF, respectively.

Conclusions:

A novel acoustic-based device (VRI) can effectively estimate LVEF.
VRI shows potential as a tool to assist in the initial triage of patients based on LVEF.
This technology may complement echocardiography for LVEF assessment.