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Related Concept Videos

Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
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The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
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Overview of Somatic Sensory Pathways01:29

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Related Experiment Video

Updated: May 29, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Do brainstem omnipause neurons terminate saccades?

Janet C Rucker1, Sarah H Ying, Willa Moore

  • 1Department of Neurology Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA. janet.rucker@mssm.edu

Annals of the New York Academy of Sciences
|September 29, 2011
PubMed
Summary
This summary is machine-generated.

Omnipause neurons (OPN) normally stop saccades, but this study found other brain mechanisms are responsible for saccade termination. This research explores saccade control in neurological conditions.

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Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
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Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

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Last Updated: May 29, 2026

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05:44

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Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
06:12

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Motor Control

Background:

  • Omnipause neurons (OPN) are known to inhibit saccade-generating burst neurons (BN).
  • OPN activity pauses before saccades and resumes at their end, suggesting a role in saccade termination.
  • Previous studies indicated OPN can stop saccades, but their pause duration doesn't always match saccade duration, and OPN lesions don't impair saccade length.

Purpose of the Study:

  • To investigate the role of OPN in saccade termination in late-onset Tay-Sachs disease and cerebellar hypermetria.
  • To identify alternative mechanisms responsible for ending saccades.

Main Methods:

  • Studied gaze shifts involving disjunctive saccades followed by vergence in patients with specific neurological conditions.
  • Observed high-frequency conjugate oscillations during vergence movements, indicating OPN silence.

Main Results:

  • High-frequency conjugate oscillations, indicative of OPN silence, were observed in all subjects during vergence movements following saccades.
  • The findings suggest that OPN are not solely responsible for saccade termination.

Conclusions:

  • Mechanisms beyond OPN discharge, such as cerebellar fastigial nucleus activity promoting inhibitory BN discharge, likely contribute significantly to saccade termination.
  • This research highlights the complexity of saccade control and identifies potential alternative pathways for saccade termination.