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Silicone breast implants--is there cause for concern?

B W Van Natta1, J B Thurston, T S Moore

  • 1Indianapolis Plastic Surgeons, IN 46260.

Indiana Medicine : the Journal of the Indiana State Medical Association
|March 1, 1990
PubMed
Summary
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Silicone-gel breast implants are safe. Rodent studies show species-specific sarcoma development, but 25 years of human use show no evidence of cancer risk.

Area of Science:

  • Biomaterials science
  • Oncology
  • Plastic surgery

Background:

  • Medical silicone-gel is used in breast implants.
  • Concerns exist regarding its potential to cause cancer.

Purpose of the Study:

  • To review the scientific literature on silicone-gel breast implants and cancer risk.
  • To assess the safety of silicone-gel breast implants for human use.

Main Methods:

  • Literature review of studies on inert materials and cancer in rodents.
  • Analysis of clinical data on human breast implant use over 25 years.

Main Results:

  • Rodents develop sarcomas from inert materials, including silicone-gel, but this is species-specific.
  • No human clinical evidence of carcinogenesis associated with silicone-gel breast implants has been found.

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Conclusions:

  • The phenomenon of sarcoma development in rodents is not applicable to humans.
  • Silicone-gel breast implants are considered safe based on available clinical evidence.