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Updated: May 29, 2026

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

A new experimental method for hiatal reinforcement using connective tissue patch transfer.

A Vereczkei1, G Varga, T Tornoczky

  • 1Departments of Surgery, Medical School University of Pécs, Pécs, Hungary. vereczkei@iseb.pote.hu

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
|September 29, 2011
PubMed
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This study explores a new, cost-effective biologic mesh for hiatal hernia repair, using cryopreserved pericardium and fascia lata grafts in dogs. Results show successful integration with minimal complications, suggesting a promising alternative for surgical reinforcement.

Area of Science:

  • Surgical Innovation
  • Biomaterials Science
  • Gastrointestinal Surgery

Background:

  • Large hiatal hernia closure presents surgical challenges.
  • Mesh reinforcement reduces recurrence but artificial meshes have higher complication rates than biologic ones.
  • A cost-effective biologic reinforcement method is needed.

Purpose of the Study:

  • To introduce and evaluate a novel, economical biologic reinforcement method for hiatoplasty.
  • To assess the integration and biocompatibility of cryopreserved pericardium and fascia lata grafts.

Main Methods:

  • Tissue islets from pericardium and fascia lata were cryopreserved.
  • Grafts were transplanted onto the diaphragm of mongrel dogs.
  • Macroscopic and microscopic examinations were performed at 1, 3, and 6 months post-transplantation.

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A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
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A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

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Last Updated: May 29, 2026

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Main Results:

  • No macroscopic signs of inflammation, abcedation, or significant adhesion were observed.
  • Grafts were recognizable, showing thickening and moderate shrinkage.
  • Microscopic analysis revealed fibrosis, neovascularization, and peritoneal integration, indicating successful tissue organization.

Conclusions:

  • Connective tissue transfer using cryopreserved or autologous tissue is a viable option for hiatoplasty reinforcement.
  • This method is inexpensive and straightforward.
  • Further testing in human interventions is recommended.