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Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...

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Updated: May 29, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Physiological roles of microglia during development.

Lorena Pont-Lezica1, Catherine Béchade, Yasmine Belarif-Cantaut

  • 1Institut de Biologie de l'Ecole Normale Supérieure, INSERM 1024 - CNRS 8197, Paris, France.

Journal of Neurochemistry
|September 29, 2011
PubMed
Summary
This summary is machine-generated.

Microglia, immune cells in the brain, exhibit consistent developmental behavior across species, suggesting a crucial physiological role. Their migration and localization patterns highlight involvement in key developmental processes.

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Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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Last Updated: May 29, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Immunology

Background:

  • Microglia are the primary immune cells of the central nervous system.
  • These cells originate from yolk sac macrophages and colonize the brain early in development.
  • Their precise roles during neurodevelopment are not fully understood.

Purpose of the Study:

  • To review the colonization patterns of microglia in the developing brain.
  • To discuss the potential physiological functions of microglia during development.
  • To highlight the stereotyped behavior of microglia across species.

Main Methods:

  • Review of existing literature on microglia development and behavior.
  • Analysis of microglia localization in relation to developmental processes.
  • Comparative examination across different species.

Main Results:

  • Microglia colonization of the central nervous system is a highly stereotyped process.
  • Early yolk sac-derived macrophages are highly proliferative.
  • Later, microglia preferentially accumulate in areas of cell death, near developing vasculature, in the marginal layer, and near radial glial cells.

Conclusions:

  • The consistent behavior of microglia during development strongly suggests a significant physiological role.
  • Microglia localization indicates involvement in critical neurodevelopmental events.
  • Further research is warranted to elucidate the specific functions of microglia in brain development.