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Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
10:38

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

Published on: September 9, 2015

Study of host-microbe interactions in zebrafish.

Kathryn Milligan-McClellan1, Jeremy R Charette, Ryan T Phennicie

  • 1Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA.

Methods in Cell Biology
|September 29, 2011
PubMed
Summary

Zebrafish are a new model for studying animal microbes. Protocols are provided for analyzing zebrafish microbes and modeling infectious diseases in these aquatic models.

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Area of Science:

  • Microbiology and Immunology
  • Developmental Biology
  • Aquatic Animal Models

Background:

  • Animals host diverse microbial communities crucial for health and disease.
  • Mice are traditional models for host-microbe interactions.
  • Zebrafish offer advantages for studying host-microbe dynamics.

Purpose of the Study:

  • To provide detailed protocols for zebrafish-associated microbial community analysis.
  • To outline methods for deriving and maintaining germ-free zebrafish.
  • To establish models for studying infectious diseases in zebrafish development.

Main Methods:

  • Analysis of zebrafish-associated microbial communities.
  • Derivation and husbandry of germ-free zebrafish.
  • Modeling infectious diseases using various inoculation routes and developmental stages.

Main Results:

  • Detailed protocols are presented for comprehensive zebrafish-microbe research.
  • Methods enable the study of microbial communities in zebrafish.
  • Germ-free zebrafish husbandry and disease modeling techniques are described.

Conclusions:

  • Zebrafish serve as a powerful model for host-microbe interaction research.
  • These protocols facilitate diverse investigations into animal-microorganism coexistence.
  • The presented methods support a wide range of microbiological and immunological studies in zebrafish.