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Related Experiment Video

Updated: May 29, 2026

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke
06:36

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

Published on: June 5, 2019

Zebrafish as a model for hemorrhagic stroke.

Matthew G Butler1, Aniket V Gore, Brant M Weinstein

  • 1Program in the Genomics of Differentiation, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA

Methods in Cell Biology
|September 29, 2011
PubMed
Summary

Zebrafish models reveal key mechanisms maintaining blood vessel integrity, crucial for understanding and preventing devastating conditions like stroke. This research highlights conserved pathways in vertebrate vascular development.

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Area of Science:

  • Vascular Biology
  • Genetics
  • Developmental Biology

Background:

  • Blood vessels are vital for transporting oxygen and nutrients, and removing waste.
  • Disruptions in blood vessel function, such as ischemia or hemorrhage, can lead to severe conditions like stroke.
  • Stroke is a complex condition influenced by genetic and environmental factors.

Purpose of the Study:

  • To explore the maintenance of vascular integrity.
  • To review seminal experiments in zebrafish related to vascular health.
  • To leverage zebrafish as a model for studying hemorrhagic stroke.

Main Methods:

  • Utilizing zebrafish embryos and larvae for experimental studies.
  • Investigating conserved molecular mechanisms of blood vascular development.

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A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
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Published on: May 31, 2021

Mechanical Vessel Injury in Zebrafish Embryos
06:38

Mechanical Vessel Injury in Zebrafish Embryos

Published on: February 17, 2015

Related Experiment Videos

Last Updated: May 29, 2026

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke
06:36

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

Published on: June 5, 2019

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
08:13

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

Published on: May 31, 2021

Mechanical Vessel Injury in Zebrafish Embryos
06:38

Mechanical Vessel Injury in Zebrafish Embryos

Published on: February 17, 2015

  • Focusing on experimental approaches applicable to zebrafish models.

    • Main Results:

    • Zebrafish models offer significant advantages for studying vascular integrity.
    • Conservation of molecular mechanisms facilitates understanding of vertebrate vascular development.
    • Seminal experiments have provided insights into vascular maintenance.

    Conclusions:

    • Zebrafish are a powerful model for investigating hemorrhagic stroke.
    • Understanding vascular integrity is key to preventing stroke.
    • Conserved mechanisms in zebrafish are relevant to human vascular health.