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A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
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Chemical screening in zebrafish for novel biological and therapeutic discovery

Justin L Tan1, Leonard I Zon

  • 1Stem Cell Program and Division of Hematology and Oncology, Children’s Hospital Boston, Dana-Farber Cancer Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, Massachusetts, USA

Methods in Cell Biology
|September 29, 2011
PubMed

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Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...