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Periventricular white matter injury by primary intraventricular hemorrhage: a diffusion tensor imaging study
Sang Seok Yeo1, Byung Yeon Choi, Chul Hoon Chang
1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
European Neurology
|September 29, 2011
Summary
Intraventricular hemorrhage (IVH) causes white matter injury in adult stroke patients. Diffusion tensor imaging (DTI) revealed fornix, corpus callosum, and corona radiata damage, impacting functional outcomes.
Area of Science:
- Neuroimaging
- Neurology
- Stroke Research
Background:
- Intraventricular hemorrhage (IVH) is a significant predictor of poor functional outcomes in adult stroke patients.
- Understanding the impact of IVH on white matter integrity is crucial for developing effective management strategies.
Purpose of the Study:
- To investigate the effects of IVH on white matter structure using diffusion tensor imaging (DTI).
- To quantify changes in white matter integrity in specific brain regions following IVH.
Main Methods:
- Recruited 10 adult patients with IVH and 18 age/sex-matched controls.
- Acquired DTI data using a 1.5-T MRI scanner approximately 84 days post-IVH onset.
- Measured fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in the fornix, corpus callosum (CC), corona radiata (CR), and posterior limb of the internal capsule (PL).
Main Results:
- DTI revealed fornix disruption in all IVH patients.
- Decreased FA values were observed in the fornix, CC, and CR.
- Increased ADC values were noted in the CC, with no significant changes in the fornix or CR. Fornix fiber number also decreased.
Conclusions:
- Periventricular white matter injury (fornix, CC, CR) occurs following intraventricular hemorrhage.
- These findings highlight the potential of DTI in assessing white matter damage post-IVH and informing treatment strategies.
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