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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
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Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: May 29, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Basic science for the clinician 53: mast cells.

Leonard H Sigal1

  • 1Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903-001, USA. lensigal@gmail.com

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|September 29, 2011
PubMed
Summary

Mast cells are crucial immune sentinels, bridging innate and adaptive immunity. Understanding their roles in inflammation and diseases like rheumatoid arthritis is key for developing new therapeutics.

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Last Updated: May 29, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells are immune sentinels located under body surfaces and in lymph nodes.
  • They are strategically positioned for early detection of pathogens.
  • Mast cells play a role in both innate and adaptive immune responses.

Purpose of the Study:

  • To highlight the critical, yet often overlooked, role of mast cells in immune responses.
  • To emphasize the potential involvement of mast cells in various autoimmune diseases and cancer.
  • To underscore the importance of studying mast cell functions for future therapeutic development.

Main Methods:

  • Review of existing literature on mast cell biology and function.
  • Analysis of mast cell location and surface markers.
  • Discussion of mast cell mediators and their impact on immune functions.

Main Results:

  • Mast cells secrete diverse mediators (prostanoids, cytokines, chemokines) that modulate immune and inflammatory functions.
  • Mast cells possess characteristics of antigen-presenting cells.
  • Their strategic location facilitates early detection and response to invaders.

Conclusions:

  • Mast cells are vital players at the innate-adaptive immune interface.
  • Further research into mast cell functions and mediators is essential for understanding immunopathogenesis.
  • Mast cells are likely implicated in diseases such as rheumatoid arthritis, scleroderma, multiple sclerosis, and cancer, offering therapeutic targets.