Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interacting effects of sex and age on immune responses in a polygynous bat with male-biased mortality.

bioRxiv : the preprint server for biology·2026

Same author

Spatial profiling of human diffuse cutaneous leishmaniasis lesions reveals immunosuppressive microenvironments that coincide with parasite localization.

The Journal of investigative dermatology·2025

Same author

Lesional senescent CD4<sup>+</sup> T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis.

Frontiers in immunology·2024

Same author

Canine Visceral Leishmaniasis: A Histological and Immunohistochemical Study of Fibropoiesis in Chronic Interstitial Pneumonitis.

Microorganisms·2024

Same author

Isolation and Culture of Bone Marrow-Derived Macrophages from Mice.

Journal of visualized experiments : JoVE·2023

Same author

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike.

PloS one·2022

Search research articles

Related Experiment Video

Updated: May 29, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Regulatory macrophages: setting the threshold for therapy.

Bryan D Fleming¹, David M Mosser

¹Department of Cell Biology and Molecular Genetics, and the Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA.

European Journal of Immunology

|September 29, 2011

Summary

Macrophages show plasticity, adapting to their environment. Understanding regulatory macrophages could lead to new anti-inflammatory therapies by targeting specific immune cell functions.

More Related Videos

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

Related Experiment Videos

Last Updated: May 29, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

Area of Science:

Immunology
Cell Biology

Background:

Macrophages are immune cells with diverse functions, including pathogen killing and immune response modulation.
Phenotypic plasticity allows macrophages to adopt different states based on environmental signals.

Purpose of the Study:

To differentiate regulatory macrophages from other activated macrophage subsets.
To explore the potential of regulatory macrophages in developing novel anti-inflammatory therapeutics.

Main Methods:

Comparative analysis of macrophage phenotypes.
Identification of unique biochemical markers for regulatory macrophages.

Main Results:

Regulatory macrophages are distinct from classically and non-classically activated macrophages.
These cells arise from different stimuli and perform unique physiological roles.
Potential unique markers for regulatory macrophages were proposed.

Conclusions:

Further understanding of macrophage phenotypes, particularly regulatory macrophages, is crucial.
Targeting specific macrophage subsets may offer new therapeutic strategies for inflammatory diseases.