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Notch in the kidney: development and disease
Yasemin Sirin1, Katalin Susztak
1Department of Nephrology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
The Journal of Pathology
|September 29, 2011
Summary
Notch signalling is crucial for kidney development and repair. Dysregulated Notch activity in the kidneys can lead to injury and fibrosis.
Area of Science:
- Cellular biology
- Developmental biology
- Renal physiology
Background:
- Notch signalling is a conserved cell-cell communication pathway vital for development and homeostasis.
- In the kidney, Notch orchestrates nephrogenesis and cell differentiation.
- Notch signalling is typically low in adult kidneys but increases during injury.
Purpose of the Study:
- To elucidate the role of Notch signalling in kidney development, repair, and injury.
- To investigate the impact of Notch dysregulation on renal pathologies.
Main Methods:
- Review of recent studies on Notch signalling in kidney development and disease.
- Analysis of the association between Notch activity and kidney injury markers.
Main Results:
- Notch signalling is essential for proximal epithelial fate and principal cell differentiation during kidney development.
- Increased Notch activity in glomerular and tubular epithelial cells is linked to albuminuria, glomerulosclerosis, and fibrosis.
- Aberrant Notch activation promotes maladaptive epithelial repair pathways, contributing to kidney fibrosis.
Conclusions:
- Notch signalling is a critical regulator of kidney development.
- Dysregulated Notch signalling significantly contributes to kidney injury and fibrosis.
- Targeting Notch pathways may offer therapeutic strategies for renal diseases.
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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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