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Updated: May 29, 2026
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Neurodevelopment of infants with prenatal exposure to polybrominated diphenyl ethers
Cherng-Gueih Shy1, Huei-Lin Huang, Gou-Ping Chang-Chien
1Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Pingtung County, 907, Taiwan.
Abstract:
The study aimed to examine the impact of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on infant neurodevelopment. PBDEs levels in 36 cord blood samples were analyzed with a high-resolution-gas-chromatograph/high-resolution-mass-spectrometer and infant neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. The mean and median of Σ(11)PBDEs were 6.63 and 4.63 ng/g lipid, respectively. As compared to the lower PBDEs group (Σ(11)PBDEs < 4.63 ng/g lipid), the higher PBDEs group (Σ(11)PBDEs > 4.63 ng/g lipid) had a significantly higher actual odds ratio (OR = 1.13, p < 0.05) of the cognition score as well as a lower odds ratio (OR = 0.904, p < 0.01) of the adaptive behavior score, suggesting that prenatal PBDEs exposure may potentially affect infant neurodevelopment.
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