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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...

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Related Experiment Video

Updated: May 29, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

Animal models of erectile dysfunction.

Petter Hedlund1, Kenshi Matsumoto, Karl-Erik Andersson

  • 1Lund University Hospital, Lund, Sweden.

Current Protocols in Pharmacology
|September 29, 2011
PubMed
Summary

Researchers evaluated rat erectile function using intracavernous pressure (ICP) measurements. This method objectively assesses autonomic nervous system effects on erection in both anesthetized and conscious rodent models.

Area of Science:

  • Urology
  • Neuroscience
  • Physiology

Background:

  • Rat neuroanatomy and corpus cavernosum (CC) morphology are well-established.
  • In vitro and molecular methods exist for rat/mouse CC tissue.
  • Rodent erectile tissue responses mimic other mammals to nerve, endothelium, or drug activation.

Purpose of the Study:

  • To objectively evaluate erectile responses via intracavernous pressure (ICP) recording.
  • To isolate and study autonomic nervous system regulatory mechanisms on erection.
  • To quantify pharmacological effects on nerve-induced erectile responses.

Main Methods:

  • Recording intracavernous pressure (ICP) in anesthetized rodents to assess peripheral nerve stimulation.
  • Utilizing a conscious rodent model to evaluate supraspinal and spinal regulatory unit activities.

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Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat
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Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat

Published on: April 23, 2018

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Last Updated: May 29, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat
07:43

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat

Published on: April 23, 2018

  • Analyzing autonomic and somatic pathway activation to the CC and penile muscles.

    • Main Results:

    • ICP recording provides objective assessment of nerve-induced erectile responses.
    • Anesthetized models allow isolation of autonomic nervous system effects.
    • Conscious models avoid anesthesia's impact on central regulatory pathways.

    Conclusions:

    • ICP measurement is a valuable tool for studying erectile function in rodents.
    • Both anesthetized and conscious models offer distinct advantages for investigating erection regulation.
    • Rodent models are suitable for understanding mammalian erectile mechanisms and pharmacological interventions.