Related Experiment Video
Updated: May 29, 2026

05:38
Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model
Published on: January 7, 2019
MPTP-induced models of Parkinson's disease in mice and non-human primates
Naomi P Visanji1, Jonathan M Brotchie
1Toronto Western Research Institute, Toronto, Ontario, Canada.
Current Protocols in Pharmacology
|September 29, 2011
Abstract:
The pro-toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely used to create animal models of Parkinson's disease. This unit describes protocols for the production of stable and substantial lesions in the dopaminergic nigrostriatal pathway of mice and non-human primates. The models can be employed for assessing the neural mechanisms underlying the development of Parkinson's disease and for screening potential therapies for the treatment of this condition.

