Related Experiment Video
Updated: May 29, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
Published on: April 19, 2013
Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension
Xiaoling Wang1, Bram P Prins, Siim Sõber
1Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA. xwang@georgiahealth.edu
Abstract:
Genetic linkage and association methods have long been the most important tools for gene identification in humans. These approaches can either be hypothesis-based (i.e., candidate-gene studies) or hypothesis-free (i.e., genome-wide studies). The first part of this review offers an overview of the latest successes in gene finding for blood pressure (BP) and essential hypertension using these DNA sequence-based discovery techniques. We further emphasize the importance of post-genome-wide association study (post-GWAS) analysis, which aims to prioritize genetic variants for functional follow-up. Whole-genome next-generation sequencing will eventually be necessary to provide a more comprehensive picture of all DNA variants affecting BP and hypertension. The second part of this review discusses promising novel approaches that move beyond the DNA sequence and aim to discover BP genes that are differentially regulated by epigenetic mechanisms, including microRNAs, histone modification, and methylation.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension I: Introduction
Hypertension II: Pathophysiology
Hypertension IV: Drug Therapy and Lifestyle Modifications