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The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

Molecular Factors Affecting Cell Division

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...

What is the Cell Cycle?

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...

What is the Cell Cycle?

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...

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Related Experiment Video

Updated: May 29, 2026

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Computational modeling of the cell cycle.

¹Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA. eric.sobie@mssm.edu

Science Signaling

|September 29, 2011

Summary

This summary is machine-generated.

This resource introduces computational biology using a simple mathematical model of the cell cycle, simulating mitosis-promoting factor (MPF) interactions. It highlights the value of simplified models in understanding complex biological processes like mitosis.

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

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Area of Science:

Computational Biology
Cell Cycle Regulation
Mathematical Modeling

Background:

The cell cycle is a fundamental biological process crucial for growth and reproduction.
Mitosis-promoting factor (MPF), composed of cyclin B and cyclin-dependent kinase 1, is a key regulator initiating mitosis.
Understanding MPF dynamics is essential for comprehending cell cycle control.

Purpose of the Study:

To provide a teaching resource for graduate students on computational biology.
To introduce a simplified mathematical model of the cell cycle focusing on MPF.
To demonstrate the utility of basic models in understanding complex biological systems.

Main Methods:

Development of a simple mathematical model simulating cyclin B and cyclin-dependent kinase 1 interactions.
Comparison of the simplified model with more detailed mechanistic models.
Implementation of the model using the MATLAB programming language.

Main Results:

The model effectively simulates the core interactions leading to MPF activation and subsequent mitosis.
Comparison reveals that simplified models can offer valuable insights into biological regulation.
The resource includes practical implementation guidance and a problem set for hands-on learning.

Conclusions:

Simplified mathematical models are powerful tools for teaching and understanding complex biological processes like the cell cycle.
Computational biology education can be effectively facilitated through accessible modeling approaches.
This resource equips students with foundational knowledge and practical skills in cell cycle modeling.