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Postoperative changes related to intraoperative blood transfusions
1Department of General Surgery, Oncology Hospital, Ankara, Turkey. seboaslan@yahoo.co.uk
Bratislavske Lekarske Listy
|September 30, 2011
Summary
Intraoperative whole-blood transfusions in breast cancer surgery may increase wound infection rates and decrease basophil counts. Further research is needed to confirm these findings and explore underlying mechanisms.
Area of Science:
- Oncology
- Immunology
- Surgical Oncology
Background:
- Growing evidence suggests whole-blood transfusions can be immunosuppressive.
- This immunosuppression may increase the risk of postoperative infections.
Purpose of the Study:
- To investigate wound infection and flap necrosis rates.
- To examine peripheral complete blood cell count changes.
- To assess the impact of intraoperative whole-blood transfusions.
Main Methods:
- A study involving 102 female breast carcinoma patients undergoing modified radical mastectomy.
- Group I received two units of whole-blood transfusions intraoperatively.
- Group II received no transfusion; complete blood cell counts, wound infection, and flap necrosis were compared.
Main Results:
- Perioperative neutrophil and monocyte counts increased significantly in the transfused group.
- Basophil counts decreased and did not normalize by postoperative day 10 in the transfused group.
- Wound infection rates were higher in the transfused group, while flap necrosis and lymphocyte counts did not differ significantly.
Conclusions:
- Intraoperative whole-blood transfusions appear to elevate wound infection risk.
- Transfusions may also lead to a decrease in basophil count.
- These findings suggest potential immunological alterations following whole-blood transfusion.
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