Related Experiment Video
Updated: May 29, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
What does ulceration of a melanoma mean for prognosis?
Glenda G Callender1, Kelly M McMasters
1Division of Surgical Oncology, Department of Surgery, University of Louisville, 315 East Broadway, Suite 312, Louisville, KY 40202, USA.
Abstract:
Ulceration of a primary cutaneous melanoma is clearly associated with worse prognosis, although the underlying mechanisms are not well understood. Recent studies have shown that the presence of ulceration may predict response to adjuvant IFN in high-risk patients. As molecular pathways continue to be elucidated, it is possible that continued study of ulceration will provide insight into potential therapeutic strategies, or will predict response to novel targeted therapies. Future investigation into melanoma ulceration is warranted.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Peptic Ulcer
Cancer Survival Analysis
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

