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Updated: May 29, 2026

Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants
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Published on: December 1, 2010

Nanostructure-based drug delivery systems for brain targeting.

Shadabul Haque1, Shadab Md, Md Intekhab Alam

  • 1Jamia Hamdard, New Delhi, India.

Drug Development and Industrial Pharmacy
|September 30, 2011
PubMed
Summary
This summary is machine-generated.

Nanostructured carriers offer a promising solution for delivering drugs across the blood-brain barrier (BBB). This review details polymeric and lipid-based nanocarriers for safe and effective central nervous system (CNS) drug delivery.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Biotechnology

Background:

  • The blood-brain barrier (BBB) restricts drug entry into the central nervous system (CNS), limiting treatment for neurological disorders.
  • Ineffective CNS drug delivery, not drug discovery, hinders the treatment of many CNS diseases.
  • Nanostructured drug delivery carriers are being developed to overcome BBB limitations.

Purpose of the Study:

  • To comprehensively review research on nanostructured carriers for safe and effective drug transport across the BBB.
  • To highlight advancements in noninvasive methods for improving drug delivery to the brain.

Main Methods:

  • Review encompasses polymeric and lipid-based nanocarriers.
  • Emphasis on utility, methodology, and advantages of different nanocarrier approaches.
  • Discussion of specific drugs and applications for nanocarrier-mediated BBB transport.

Main Results:

  • Polymeric and lipid nanocarriers can enter brain capillaries without disrupting the BBB.
  • Surface modification with ligands and pegylation enhances targeting and brain tissue binding.
  • These modifications increase circulation time, favoring interaction and penetration into brain endothelial cells.

Conclusions:

  • This review provides insights for researchers in neurodegenerative and non-neurodegenerative CNS diseases.
  • The findings are relevant for developing treatments for conditions like brain tumors.
  • Nanocarrier strategies offer a pathway to improved therapeutic interventions for CNS disorders.