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Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
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Published on: January 16, 2013

Schistosomiasis and pulmonary hypertension.

Caio Julio Cesar Dos Santos Fernandes1, Carlos Viana Poyares Jardim, André Hovnanian

  • 1Pulmonary Department, Heart Institute, University of São Paulo Medical School, São Paulo, Brazil.

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Schistosomiasis, a widespread infectious disease, can lead to pulmonary hypertension (Sch-PH), potentially the most common cause globally. This article explores Sch-PH

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Area of Science:

  • Tropical medicine
  • Cardiology
  • Infectious diseases

Background:

  • Schistosomiasis is a globally prevalent chronic infectious disease.
  • Hepatosplenic schistosomiasis can cause pulmonary hypertension (Sch-PH) in up to 5% of patients.
  • Sch-PH may be the most common cause of pulmonary hypertension worldwide due to schistosomiasis prevalence.

Purpose of the Study:

  • To discuss the physiopathological mechanisms of schistosomiasis-associated pulmonary hypertension.
  • To review the clinical course of Sch-PH.
  • To examine the response to available treatments for Sch-PH.

Main Methods:

  • Literature review of potential disease mechanisms.
  • Analysis of clinical data on disease progression.
  • Evaluation of treatment efficacy.

Main Results:

  • Multiple pathways contribute to Sch-PH, including egg embolism, inflammation, and pulmonary blood overflow.
  • The clinical course and treatment responses vary.
  • Further research is needed to fully elucidate mechanisms and optimize treatment.

Conclusions:

  • Sch-PH is a significant complication of schistosomiasis with diverse underlying mechanisms.
  • Understanding these mechanisms is crucial for effective management.
  • Current treatment strategies require further investigation and refinement.