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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

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Published on: August 9, 2012

[Cystitis and ketamine associated bladder dysfunction].

A García-Larrosa1, C Castillo, M Ventura

  • 1Servicio de Urología, Hospital del Mar, Barcelona, España. garcialarrosa@yahoo.es

Actas Urologicas Espanolas
|September 30, 2011
PubMed
Summary
This summary is machine-generated.

Recreational ketamine use is linked to lower urinary tract symptoms (LUTS) in nearly half of users. Higher doses and daily use significantly increase the risk and severity of these urinary issues.

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Area of Science:

  • Urology
  • Toxicology
  • Pharmacology

Background:

  • Recreational ketamine use is increasing globally.
  • Ketamine is known to have potential toxic effects on various organs.
  • Urinary tract symptoms are a reported, yet not fully understood, consequence of ketamine abuse.

Purpose of the Study:

  • To investigate the prevalence of lower urinary tract symptoms (LUTS) among recreational ketamine users.
  • To explore the correlation between ketamine consumption patterns and the occurrence of LUTS.

Main Methods:

  • A cohort of 13 recreational ketamine users was evaluated.
  • Data collected included the presence of LUTS, gross hematuria, and lumbar spine pain.
  • Ketamine usage patterns (initiation, route, dose, frequency) were meticulously recorded.

Main Results:

  • 46% of users reported LUTS, characterized by frequent urination, dysuria, urgency, and pain.
  • Symptomatic users consumed significantly higher daily doses (3g/day) of inhaled ketamine compared to asymptomatic users (1.03g/day).
  • Symptom severity correlated with ketamine dose and frequency, improving with increased water intake.

Conclusions:

  • A clear relationship exists between ketamine consumption patterns (dose, frequency) and the development of LUTS.
  • Ketamine's detrimental effect on the urothelium is hypothesized as the primary mechanism.
  • Early identification and cessation of ketamine use are crucial for managing these symptoms.