Related Experiment Video
Updated: May 29, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Synthesis of lipids for development of multifunctional lipid-based drug-carriers
Guodong Zhu1, Yahya Alhamhoom, Brian S Cummings
1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, 215 W. Green Street, Rm 220 Athens, GA 30602 2352, United States.
Abstract:
A simple approach to synthesize phospholipids to modulate drug release and track lipid-based particulate drug-carriers is described. We synthesized two ether lipids, 1 1-O-hexadecyl-2-pentadenoyl-sn-glycerol-3-phosphocholine (C(31)PC) and 2 1-O-hexadecyl-2-pentadenoyl-sn-glycerol-3-phosphomethanol (C(31)PM), and examined their ability to alter enzymatically triggered release of 6-carboxyfluorescein from liposomes incubated in TRIS buffer or fetal bovine serum solutions. Further, we demonstrated that odd-chain lipids, for example, C(31)PC, could be identified in rat plasma without interference of endogenous lipids. This approach can be adapted to synthesize a variety of lipids for use in developing and optimizing multifunctional drug-carriers.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Biosynthesis of Lipids
Synthesis of Phosphatidylcholine in the ER Membrane
The major components of all eukaryotic cell...
Bioavailability Enhancement: Drug Permeability Enhancement
Lipids as Anchors
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...
Drug Biotransformation: Overview

