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Updated: May 29, 2026
06:48
Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
Published on: April 29, 2022
Gender-dependent effects of aging on the kidney
A L Gava1, F P S Freitas, S S Meyrelles
1Laboratório de Transgenes e Controle Cardiovascular, Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.
Summary
Aging kidneys are susceptible to cardiovascular diseases, influenced by sex hormones. This review explores how sex steroids impact kidney function and cardiovascular health throughout life, particularly during aging.
Area of Science:
- Nephrology
- Endocrinology
- Cardiology
Background:
- Kidney health is crucial for cardiovascular disease (CVD) prevention, with aging increasing CVD risk.
- Normal aging alters kidney structure, hemodynamics, and function, elevating cardiovascular event incidence in older adults.
- Gender influences these age-related cardiorenal disturbances, with estrogens offering protection in females.
Purpose of the Study:
- To review the cellular, biochemical, and molecular mechanisms of sex hormone influence on kidney function during aging.
- To elucidate the less understood roles of androgens in kidney health across the lifespan.
- To understand how declining sex steroid levels impact renal reserve and contribute to cardiovascular disorders.
Main Methods:
- Literature review of studies on sex hormones, kidney function, and aging.
- Analysis of cellular, biochemical, and molecular pathways.
- Exploration of gender-specific effects on the cardiorenal system.
Main Results:
- Estrogens demonstrate protective effects on renal function in the elderly.
- Androgen roles in kidney health and aging require further investigation.
- Declining sex steroid levels with age impair kidney function and increase cardiovascular risk.
Conclusions:
- Sex hormones significantly modulate kidney function and cardiorenal health during aging.
- Understanding these mechanisms is vital for developing targeted interventions for age-related cardiovascular diseases.
- Further research into androgen-kidney interactions is warranted.
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