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Updated: May 29, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Preparation of glutamate analogues by enzymatic transamination
Thierry Gefflaut1, Zeinab Assaf, Martine Sancelme
1Lab SEESIB, Clermont Université, Université Blaise Pascal - CNRS, Aubière, France. Thierry.gefflaut@univ-bpclermont.fr
Abstract:
Aminotransferases are key enzymes of the metabolism of proteinogenic amino acids. These ubiquitous biocatalysts show high specific activities and relaxed substrate specificities making them valuable tools for the stereoselective synthesis of unnatural amino acids. We describe here the application of aspartate aminotransferase and branched chain aminotransferase from E. coli for the synthesis of various glutamate analogues, molecules of particular interest regarding the neuroactive properties of glutamic acid.
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