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Updated: May 29, 2026
11:09
Chromatin Isolation by RNA Purification (ChIRP)
Published on: March 25, 2012
Long noncoding RNAs in mammalian cells: what, where, and why?
Ling-Ling Chen1, Gordon G Carmichael
1Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. linchen@uchc.edu
Wiley Interdisciplinary Reviews. RNA
|September 30, 2011
Summary
Many cellular RNAs, known as long noncoding RNAs (lncRNAs), do not encode proteins. These lncRNAs play crucial roles in regulating gene expression and nuclear organization in mammalian cells.
Area of Science:
- Molecular Biology
- Genomics
- Cell Biology
Background:
- Cellular RNA transcripts are not exclusively protein-coding.
- A significant portion of cellular RNA, including long noncoding RNAs (lncRNAs), lacks open reading frames or is retained in the nucleus.
- These non-coding transcripts are increasingly recognized for their functional importance.
Purpose of the Study:
- To review recent advancements in understanding the functions of lncRNAs in mammalian cells.
- To highlight the roles of specific lncRNAs in cellular processes.
Main Methods:
- Literature review of recent studies on lncRNA function.
- Analysis of published data on lncRNA roles in nuclear architecture and gene regulation.
Main Results:
- lncRNAs are abundant and functionally significant in mammalian cells.
- Specific lncRNAs have been identified to play key roles in nuclear organization.
- lncRNAs are involved in the regulation of gene expression.
Conclusions:
- lncRNAs are critical regulators of cellular processes.
- Further research into lncRNA function is essential for understanding mammalian cell biology.
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