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Updated: May 29, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Impact of pericentric inversion of Chromosome 9 [inv (9) (p11q12)] on infertility
Hossein Mozdarani1, Anahita Mohseni Meybodi, Hamideh Karimi
1Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Background:
One of the frequent occurrences in chromosome rearrangements is pericentric inversion of the Chromosome 9; inv (9) (p11q12), which is consider to be the variant of normal karyotype. Although it seems not to correlate with abnormal phenotypes, there have been many controversial reports indicating that it may lead to abnormal clinical conditions such as infertility. The incidence is found to be about 1.98% in the general population.
Materials And Methods:
We investigated the karyotypes of 300 infertile couples (600 individuals) being referred to our infertility clinic using standard GTG banding for karyotype preparation.
Results:
The chromosomal analysis revealed a total of 15 (2.5%) inversions, among these, 14 male patients were inversion 9 carriers (4.69%) while one female patient was affected (0.33%). The incidence of inversion 9 in male patients is significantly higher than that of normal population and even than that of female patients (P< 0.05).
Conclusions:
This result suggests that inversion 9 may often cause infertility in men due to spermatogenic disturbances, which are arisen by the loops or acentric fragments formed in meiosis.
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