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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

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A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

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Published on: June 5, 2014

Redefining latent tuberculosis.

Saranya Sridhar1, Katrina Pollock, Ajit Lalvani

  • 1Tuberculosis Research Unit, Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK.

Future Microbiology
|October 1, 2011
PubMed
Summary
This summary is machine-generated.

Tuberculosis (TB) is a global health issue, with latent TB infection acting as a reservoir. Recent immunological advances are redefining latent TB, paving the way for better diagnostics and control strategies.

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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Published on: September 5, 2017

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Last Updated: May 29, 2026

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
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Published on: June 5, 2014

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Area of Science:

  • Immunology
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global public health challenge.
  • Latent TB infection (LTBI) serves as the primary reservoir for TB transmission.
  • Traditional methods for diagnosing TB include clinical symptoms, tuberculin skin tests, and chest X-rays.

Purpose of the Study:

  • To review the conventional understanding of latent TB infection.
  • To discuss how immunological advancements have redefined LTBI.
  • To explore future directions in TB immunology and diagnostics for improved public health strategies.

Main Methods:

  • Review of existing literature on TB natural history and immunology.
  • Analysis of the impact of Interferon-gamma (IFN-γ) release assays and other immunological tools.
  • Discussion of current and emerging diagnostic technologies.

Main Results:

  • Immunology has redefined latent TB as a spectrum of pathogen burden and host immune control.
  • Newer immunological tools offer a more nuanced understanding of LTBI compared to traditional methods.
  • Advances in diagnostics are crucial for effective TB control.

Conclusions:

  • The understanding of latent TB has evolved significantly due to immunological research.
  • Future strategies for TB control will heavily rely on advancements in TB immunology and diagnostics.
  • Integrating novel diagnostic approaches is essential to manage the global TB burden.