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Related Experiment Video

Updated: May 29, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

Sperm morphology: classification drift over time and clinical implications.

Dean E Morbeck¹, Phoebe H Leonard, Amy L Weaver

¹Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA. morbeck.dean@mayo.edu

Fertility and Sterility

|October 1, 2011

Summary

This summary is machine-generated.

Sperm morphology assessment for intrauterine insemination (IUI) showed a decline in predictive value over time. This suggests classification drift in diagnosing teratozoospermia may impact IUI success rates.

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Area of Science:

Reproductive Medicine
Sperm Analysis
Intrauterine Insemination

Background:

Sperm morphology is a key factor in assessing male fertility.
Standardized criteria for sperm morphology assessment are crucial for accurate diagnosis and treatment planning.

Purpose of the Study:

To compare sperm morphology assessments using Tygerberg (strict) and World Health Organization (WHO) 3rd criteria between two distinct time periods.
To evaluate the impact of changes in morphology assessment on intrauterine insemination (IUI) pregnancy rates.

Main Methods:

Retrospective study conducted at an academic institution.
Analysis of data from 127 couples (290 IUI treatments) in 1996-97 (era 1) and 133 couples (317 IUI treatments) in 2005-06 (era 2).
Pregnancy rates per cycle and per couple were the primary outcome measures.

Main Results:

Sperm morphology was significantly better in era 1 compared to era 2 by both WHO 3rd and strict criteria.
Pregnancy rates per cycle showed a stronger association with morphology in era 1 than in era 2.
In era 2, pregnancy rates were less dependent on morphology thresholds compared to era 1.

Conclusions:

A strong correlation between sperm morphology and IUI outcomes existed in era 1 but diminished in era 2.
Classification drift in sperm morphology assessment may have increased diagnoses of teratozoospermia.
The loss of predictive value in morphology assessment could affect the interpretation of IUI success rates.