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Updated: May 29, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Brucellosis relapse causing prosthetic valve endocarditis and aortic root infective pseudoaneurysm
Ahmad Ali Amirghofran1, Ashkan Karimi, Abbas Emaminia
1Division of Cardiothoracic Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
This case study details a patient with brucellosis and aortic root replacement who developed prosthetic valve endocarditis. Successful management involved surgery and antibiotics for Brucella infection.
Area of Science:
- Infectious Diseases
- Cardiovascular Surgery
- Bacteriology
Background:
- Brucellosis is a zoonotic infection that can affect multiple organ systems.
- Aortic root replacement is a complex surgical procedure with potential complications.
- Prosthetic valve endocarditis poses a significant risk following cardiac surgery.
Observation:
- A patient with a history of brucellosis and aortic root replacement developed prosthetic valve endocarditis.
- A massive aortic root pseudoaneurysm was identified as a complication.
- Preoperative and intraoperative cultures confirmed Brucella infection in blood and pseudoaneurysm tissue.
Findings:
- The patient's Brucella endocarditis and pseudoaneurysm were successfully treated with a combined surgical and medical approach.
- Aggressive antimicrobial therapy targeting Brucella was crucial for patient recovery.
- This case highlights the challenges in managing recurrent Brucella infections in cardiovascular settings.
Implications:
- Early diagnosis and comprehensive treatment are vital for managing Brucella endocarditis after aortic surgery.
- Multidisciplinary collaboration between infectious disease specialists and cardiac surgeons is essential.
- Further research into optimal management strategies for complex Brucella cardiovascular infections is warranted.
Related Concept Videos
Endocarditis I: Introduction
Rheumatic Heart Disease I: Introduction
Endocarditis III: Medical Management
Endocarditis II: Clinical Features of Infective Endocarditis
Aortic Regurgitation I: Introduction
Aortic Regurgitation II: Clinical Features and Diagnostic Tests

