Related Experiment Video
Updated: May 29, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
B cells in clinical transplantation tolerance
Andrew B Adams1, Kenneth A Newell
1Department of Surgery and the Emory Transplant Center, Emory University, Atlanta, GA 30322, USA.
Seminars in Immunology
|October 1, 2011
Summary
Researchers are investigating the role of B cells in achieving transplant tolerance. Identifying these mechanisms could lead to better monitoring and treatments for transplant recipients.
Area of Science:
- Immunology
- Transplantation Science
Background:
- Clinical transplantation tolerance is rare, hindering mechanistic studies.
- Recent studies link B cell populations with inhibitory phenotypes to tolerance in kidney transplant recipients.
Purpose of the Study:
- To investigate the role of B cells in clinical transplantation tolerance.
- To identify mechanisms by which B cells may regulate immune responses post-transplant.
Main Methods:
- Analysis of B cell populations in kidney transplant recipients.
- Correlation of B cell numbers and phenotypes with transplant tolerance status.
Main Results:
- Association observed between increased numbers of B cells (with less mature, inhibitory phenotypes) and transplant tolerance.
- Experimental models suggest B cells can regulate immune responses.
Conclusions:
- B cells may play a causative role in clinical transplantation tolerance.
- Further research is needed to confirm B cell involvement and elucidate underlying mechanisms.
- Understanding these mechanisms is crucial for developing targeted monitoring and immunosuppressive strategies to promote tolerance.
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