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The coronary collateral circulation: genetic and environmental determinants in experimental models and humans

Paul F A Teunissen1, Anton J G Horrevoets, Niels van Royen

  • 1Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.

Journal of Molecular and Cellular Cardiology
|October 1, 2011
PubMed

Insights

Coronary artery obstruction triggers collateral vessel growth, but patient capacity varies significantly. Genetic and non-genetic factors influence this arteriogenic response, impacting coronary blood flow.

Area of Science:

  • Cardiovascular Science
  • Genetics
  • Physiology

Background:

  • Coronary artery obstruction initiates an arteriogenic response, involving collateral network enlargement to compensate for reduced blood flow.
  • Significant patient-to-patient variability exists in the development of coronary collateral circulation.
  • This heterogeneity suggests a crucial role for both genetic and environmental factors.

Purpose of the Study:

  • To review the genetic and non-genetic determinants contributing to the heterogeneity of coronary collateral circulation.
  • To explore the factors influencing the arteriogenic response in coronary artery disease.

Main Methods:

  • Literature review focusing on studies investigating coronary collateral circulation.
  • Analysis of genetic and non-genetic factors influencing arteriogenesis.
  • Synthesis of current knowledge on the variability of collateral development.

Main Results:

  • Coronary collateral circulation capacity is highly heterogeneous among individuals and species.
  • Both genetic predispositions and environmental influences significantly shape the arteriogenic response.
  • Understanding these determinants is key to addressing perfusion deficits.

Conclusions:

  • The development of coronary collateral circulation is influenced by a complex interplay of genetic and non-genetic factors.
  • This variability is a critical consideration in managing patients with coronary artery disease.
  • Further research into these determinants could lead to improved therapeutic strategies.

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