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Related Experiment Video

Updated: May 29, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Kidney abnormalities in sickle cell disease.

K López Revuelta¹, M P Ricard Andrés

¹Nephrology Department, Fundación Alcorcón University Hospital, Madrid, Spain. klopez@fhalcorcon.es

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia

|October 1, 2011

Summary

Sickle cell disease causes widespread kidney damage, affecting all nephron parts. Early recognition and specialized treatment are crucial for managing renal complications in sickle cell patients.

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Published on: March 14, 2017

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Last Updated: May 29, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Nephrology
Hematology

Background:

Sickle cell disease (SCD) is associated with diverse renal abnormalities affecting the entire nephron.
These abnormalities occur across SCD genotypes, including sickle cell anemia, compound heterozygous states, and sickle cell trait.

Purpose of the Study:

To summarize the renal manifestations of sickle cell disease.
To highlight the importance of specialized knowledge for managing these kidney complications.
To disseminate the renal chapter from the Spanish Haemathology and Hemotherapy Association's Clinical Practice Guidelines on SCD management.

Main Methods:

Review of existing literature and clinical guidelines on sickle cell nephropathy.
Reproduction of the renal chapter from the Spanish Haemathology and Hemotherapy Association's Clinical Practice Guidelines.

Main Results:

Sickle cell disease leads to significant structural and functional kidney abnormalities.
Common renal issues include hematuria, proteinuria, tubular dysfunction, and chronic kidney disease.
Changes are most severe in homozygous sickle cell anemia but present in other genotypes as well.

Conclusions:

Renal complications are a major concern in sickle cell disease management.
Understanding distinct pathogenic mechanisms is vital for effective therapy.
The provided guidelines offer essential information for nephrologists and hematologists.