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Analysis of some biochemical and haematological parameters for Mucuna pruriens (DC) seed powder in male rats
Ndukwe Henry Chukwudi1, Omale Simeon, Aguiyi John Chinyere
1Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria. chuksemail@yahoo.com
Abstract:
The biochemical and haematological effects of the seed powder of Mucuna pruriens in male rats were evaluated to establish some biological properties of this potential biopesticide currently undergoing investigation. The result showed that Mucuna pruriens seed extract produced a significant (p<0.05) increase in white blood cell (WBC) count, as well as in bilirubin concentrations, alkaline phosphatase (ALP), protein and creatinine levels measured. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly reduced (P<0.05) in comparison with the experimental control. PCV, Hb, albumin level and WBC differential counts gave no significant difference between treated and control groups. The results revealed metabolic imbalance in the rats which suggests a mild cholestasis effect of the extract.
Insights
Mucuna pruriens seed extract significantly altered biochemical markers in male rats, increasing white blood cell (WBC) count and liver enzymes, suggesting potential metabolic effects and mild cholestasis.
Area of Science:
- Biochemistry
- Hematology
- Toxicology
Background:
- Mucuna pruriens seeds are being investigated as a potential biopesticide.
- Understanding the biochemical and haematological effects is crucial for safety assessment.
Purpose of the Study:
- To evaluate the biochemical and haematological effects of Mucuna pruriens seed powder in male rats.
- To establish biological properties relevant to its potential biopesticide application.
Main Methods:
- Male rats were administered Mucuna pruriens seed extract.
- Biochemical parameters including liver enzymes (ALP, ALT, AST), bilirubin, protein, albumin, and creatinine were measured.
- Haematological parameters such as packed cell volume (PCV), hemoglobin (Hb), and white blood cell (WBC) differential counts were analyzed.
Main Results:
- A significant increase (p<0.05) in WBC count, bilirubin, alkaline phosphatase (ALP), protein, and creatinine levels was observed.
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly reduced (P<0.05).
- No significant differences were found in PCV, Hb, albumin, and WBC differential counts between treated and control groups.
Conclusions:
- Mucuna pruriens seed extract induced metabolic imbalance in rats.
- The observed changes suggest a mild cholestasis effect of the extract.
- Further research is needed to fully elucidate the toxicological profile of Mucuna pruriens as a biopesticide.