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Development of meloxicam formulations utilizing ternary complexation for solubility enhancement
Saraf Shubhini Awasthi1, Tripathi Girish Kumar, Pandey Manisha
1Faculty of Pharmacy, BBDNITM, Lucknow, India.
Pakistan Journal of Pharmaceutical Sciences
|October 1, 2011
Summary
This study improved Meloxicam solubility using solid dispersion with beta-cyclodextrin and HPMC. The enhanced Meloxicam formulations show significantly increased drug solubility and bioavailability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Meloxicam, an NSAID, exhibits poor water solubility, impacting its bioavailability.
- Low solubility affects drug absorption, C(max), T(max), and overall therapeutic efficacy.
Purpose of the Study:
- To enhance the dissolution and solubility of Meloxicam.
- To develop improved Meloxicam formulations using solid dispersion technology.
Main Methods:
- Preparation of Meloxicam solid dispersions using beta-cyclodextrin with various water-soluble polymers (HPMC, methylcellulose, PVP K30).
- Phase solubility studies to assess solubilizing power.
- Formulation of solid dispersions into tablets and suspensions for evaluation.
Main Results:
- Solid dispersion significantly increased Meloxicam solubility to 90 µg/ml.
- Beta-cyclodextrin blended with 0.12% w/w HPMC (Methocel IH) proved most effective.
- Formulations demonstrated superior drug solubility compared to native Meloxicam.
Conclusions:
- Solid dispersion technique, particularly with ternary complexation, is a valuable method for enhancing drug solubility.
- Optimized formulations using beta-cyclodextrin and HPMC offer improved Meloxicam delivery.
- This approach leads to superior drug formulations with enhanced bioavailability potential.
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