Related Experiment Video
Updated: May 28, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Unusual physical features and heat stroke presentation for hypohydrotic ectodermal dysplasia
Pankaj Prasun1, Swati A Karmarkar, Ajay Agarwal
1Children's Hospital of Michigan Department of Radiology, Detroit Medical Center, Detroit, Michigan, USA.
Abstract:
Hypohidrotic/ anhidrotic ectodermal dysplasia (HED) is characterized by hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (decreased tooth development). Sweating is either absent or greatly deficient leading to an increased risk for hyperthermia. This is a relatively common genetic condition; it is estimated that 1 in approximately 5000–10 000 newborns has HED (Wright et al., 2009). Here, we report an infant with HED who presented with a heat stroke-like condition in the extreme winter months of Michigan.
Related Concept Videos
Homeostatic Imbalances in Body Temperature
Decreased Body Temperature
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Hyperosmolar Hyperglycemic State
Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Increased Body Temperature

