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Related Experiment Video

Updated: May 28, 2026

A Preclinical Model of Exertional Heat Stroke in Mice

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Unusual physical features and heat stroke presentation for hypohydrotic ectodermal dysplasia.

Pankaj Prasun¹, Swati A Karmarkar, Ajay Agarwal

¹Children's Hospital of Michigan Department of Radiology, Detroit Medical Center, Detroit, Michigan, USA.

Clinical Dysmorphology

|October 1, 2011

Summary

Hypohidrotic/anhidrotic ectodermal dysplasia (HED) is a genetic disorder affecting hair, teeth, and sweat glands. An infant with HED experienced a heat stroke-like event despite cold Michigan winter conditions.

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Area of Science:

Genetics
Pediatrics
Dermatology

Background:

Hypohidrotic/anhidrotic ectodermal dysplasia (HED) is a genetic disorder affecting ectodermal structures.
Key features include hypotrichosis, hypohidrosis, and hypodontia.
Reduced sweating capacity significantly increases the risk of hyperthermia.

Observation:

This report details an infant diagnosed with HED.
The infant presented with symptoms mimicking heat stroke.
This occurred during the winter months in Michigan.

Findings:

The case highlights a severe presentation of HED.
It demonstrates the potential for hyperthermia even in cold environments.
The infant's condition underscores the critical role of thermoregulation in HED patients.

Implications:

Early recognition of HED is crucial for managing thermoregulation.
Environmental factors can exacerbate HED-related risks.
This case emphasizes the need for vigilant monitoring of HED patients, irrespective of ambient temperature.