Related Experiment Video
Updated: Feb 10, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Cardiovascular involvement in patients with systemic sclerosis: insights from electromechanical characteristics of
Can Yücel Karabay1, Tansu Karaahmet, Kürşat Tigen
1Cardiology Clinic, Kartal Koşuyolu Training and Research Hospital, İstanbul-Turkey.
Insights
Systemic sclerosis can affect the heart, impacting survival. Early detection using non-invasive methods is crucial for managing cardiac involvement and improving patient outcomes in this autoimmune disease.
Area of Science:
- Cardiology
- Rheumatology
- Autoimmune Diseases
Background:
- Systemic sclerosis is a severe autoimmune disease affecting multiple organs, including the heart.
- Cardiac involvement is a significant predictor of mortality in systemic sclerosis.
- Involvement can affect the myocardium, conduction system, vasculature, and pericardium, potentially causing pulmonary hypertension.
Purpose of the Study:
- To review cardiac involvement in systemic sclerosis.
- To discuss clinical diagnostic modalities for assessing cardiac involvement.
- To highlight the importance of early detection and non-invasive techniques.
Main Methods:
- Review of current literature on systemic sclerosis and cardiac involvement.
- Discussion of non-invasive imaging techniques for cardiac assessment.
- Focus on electromechanical properties of the atrium and ventricles.
Main Results:
- Cardiac involvement is frequently encountered in systemic sclerosis.
- Non-invasive evaluation aids in early prognosis prediction.
- Novel imaging techniques enhance detection rates.
Conclusions:
- Early detection of cardiac involvement in systemic sclerosis is essential.
- Non-invasive diagnostic modalities are vital for risk stratification.
- Therapeutic strategies can be optimized with timely diagnosis.
Abstract:
Systemic sclerosis is a severe, life threatening autoimmune disease involving the skin and visceral organs, including the lungs, gastrointestinal tract, kidneys and heart. Cardiac involvement in systemic sclerosis, which is an important mortality predictor may involve myocardium, conduction system, vascular wall, pericardium, pulmonary vessels causing pulmonary hypertension. Thus, the detection of cardiac involvement is necessary in systemic sclerosis. With the more widespread use of novel non-invasive imaging techniques, the cardiac involvement is more frequently encountered in daily practice. Noninvasive evaluation can offer an advantage in early prediction of poor prognosis and give a chance to apply new therapeutic approaches for cardiac involvement. In this review, we intend to present cardiac involvement of systemic sclerosis and clinical diagnostic modalities, including electromechanical properties of the atrium and ventricles, for assessment this involvement.
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