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Updated: May 28, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Detection of active plaques in multiple sclerosis using susceptibility-weighted imaging: comparison with

Masako Suzuki1, Kohsuke Kudo, Makoto Sasaki

  • 1Department of Neurology, Iwate Medical University, Morioka, Japan.

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
|October 1, 2011
PubMed
Abstract

Insights

Susceptibility-weighted magnitude imaging shows promise in identifying active multiple sclerosis (MS) plaques. This MRI technique can predict contrast enhancement in MS plaques with high specificity, aiding in diagnosis.

Area of Science:

  • Radiology
  • Neuroimaging
  • Magnetic Resonance Imaging

Background:

  • Susceptibility-weighted (SW) imaging is an MRI technique used for visualizing multiple sclerosis (MS) plaques.
  • The ability of SW imaging to differentiate active MS plaques is not well-established.

Purpose of the Study:

  • To evaluate the effectiveness of SW imaging in detecting active MS plaques.
  • To compare SW imaging with contrast-enhanced MRI for identifying active plaques.

Main Methods:

  • Prospective study of 11 patients using a 3-tesla scanner.
  • Two neuroradiologists independently assessed 74 plaques on various SW image types (magnitude, phase, minIP) and contrast-enhanced T1-weighted images (T1WI).
  • Statistical analysis (Fisher's exact test) correlated SW signal alterations with contrast enhancement to determine sensitivity and specificity.

Main Results:

  • Plaque signal changes on SW magnitude images significantly correlated with contrast enhancement (P=0.008).
  • High signal intensity on SW magnitude images demonstrated 0.556 sensitivity and 0.787 specificity for predicting contrast-enhanced plaques.
  • Low signal rims around plaques showed 0.296 sensitivity and 0.957 specificity for predicting contrast enhancement.

Conclusions:

  • SW magnitude imaging can predict MS plaques with contrast enhancement with high specificity.
  • SW phase and minimum intensity projection (minIP) images were not effective in predicting contrast enhancement.

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