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Updated: May 28, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Pituitary function impairment after moderate traumatic brain injury.

Mohammad Reza Hadji Abadi¹, Mohammad Ghodsi, Masoud Merazin

¹Department of Neurosurgery, School of Medicine, Tehran University of Medical Sciences, Iran.

Acta Medica Iranica

|October 1, 2011

Summary

Moderate traumatic brain injury (TBI) can cause pituitary hormone deficiencies, particularly affecting IGF-1 and LH/FSH. These deficiencies tend to decrease over time post-injury.

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Last Updated: May 28, 2026

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Published on: November 19, 2012

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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Published on: August 14, 2019

Area of Science:

Neuroendocrinology
Trauma Surgery

Background:

Moderate traumatic brain injury (TBI) can lead to significant long-term health complications.
Pituitary hormone deficiencies are a potential consequence of TBI, impacting various bodily functions.

Purpose of the Study:

To investigate the prevalence and pattern of pituitary hormone deficiencies following moderate TBI.
To assess the temporal changes in these deficiencies.

Main Methods:

Prospective cohort study including 75 patients with moderate TBI (GCS 9-13).
Pituitary hormone levels were assessed at 3 and 6 months post-injury.
Hormone levels included IGF-1 and LH/FSH, among others.

Main Results:

At 3 months post-injury, 26% of patients had one hormone deficiency, 8% had two, and 2% had three.
By 6 months, 21 patients showed a single hormone deficiency, and one patient had two deficiencies.
Insulin-like Growth Factor 1 (IGF-1) and Luteinizing Hormone/Follicle-Stimulating Hormone (LH/FSH) deficiencies were most common.
Overall pituitary dysfunction decreased from 3 to 6 months post-injury.

Conclusions:

Moderate TBI is associated with a notable prevalence of pituitary hormone deficiencies.
The most affected hormones are IGF-1 and LH/FSH.
Pituitary hormone deficiencies show a trend of improvement over time after moderate TBI.