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Wandering Ozurdex(®) implant.

Reema Bansal¹, Pooja Bansal, Pandurang Kulkarni

¹Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Journal of Ophthalmic Inflammation and Infection

|October 1, 2011

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Intravitreal Ozurdex (dexamethasone intravitreal implant) showed initial improvement in post-lensectomy-vitrectomy (PLV) aphakia eyes but frequently migrated, causing corneal edema. Ozurdex is contraindicated in PLV aphakia due to risks to corneal endothelium.

Area of Science:

Ophthalmology
Retinal Diseases
Ocular Surgery

Background:

Post-lensectomy-vitrectomy (PLV) aphakia presents unique challenges for intraocular treatments.
Intravitreal corticosteroid implants are used for various ocular inflammatory and edematous conditions.

Purpose of the Study:

To evaluate the behavior and outcomes of intravitreal Ozurdex (dexamethasone intravitreal implant) in eyes with PLV aphakia.

Main Methods:

Retrospective chart review of three eyes with PLV aphakia and uveitis.
Ozurdex implant injections were administered for cystoid macular edema, persistent inflammation, and ocular hypotony.
Outcomes assessed included implant effectiveness, stability, and tolerance.

Main Results:

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Initial clinical improvement observed in all three eyes post-injection.
Implant migration into the anterior chamber occurred in all eyes within 1-5 weeks.
Corneal edema developed in two eyes, necessitating implant removal in one case.

Conclusions:

Intravitreal Ozurdex implants are associated with significant risks in eyes with PLV aphakia.
Implant migration and subsequent corneal endothelium damage are major concerns.
Contraindication of Ozurdex in PLV aphakia is recommended to prevent adverse ocular effects.