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Transplant glomerulopathy: it's not always about chronic rejection

Mark Haas

    Kidney International
    |October 1, 2011
    PubMed

    Transplant glomerulopathy (TG) is a morphologic lesion of renal allografts characterized by duplication of the glomerular basement membrane and is widely accepted as a manifestation of chronic antibody-mediated rejection (AMR). However, TG is not specific for chronic AMR, and this pattern of injury may result from a number of disease processes affecting the glomerular endothelium. Baid-Agrawal and co-workers consider three different, but not mutually exclusive, processes that can produce morphologic lesions of TG: chronic AMR, hepatitis C, and thrombotic microangiopathy.

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