Covalent cross-linking of kinases with their corresponding peptide substrates

Alexander V Statsuk1, Kevan M Shokat

  • 1Department of Chemistry, Northwestern University, Evanston, IL, USA.

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Covalently Linked Protein Regulators02:04

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These groups modify specific amino acids in a protein.
Covalently Linked Protein Regulators02:04

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
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Protein Kinases and Phosphatases02:54

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