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[New therapy using bisphosphonate for urolithiasis].

Takahiro Yasui¹, Kazuhiro Niimi, Masahito Hirose

¹Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Japan.

Clinical Calcium

|October 1, 2011

Summary

Bisphosphonates, used for osteoporosis, can prevent the recurrence of urolithiasis by reducing urinary calcium excretion. This dual action suggests a new therapeutic approach for patients with bone density loss and kidney stones.

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Area of Science:

Nephrology
Endocrinology
Bone Metabolism

Context:

Osteoporosis is a condition marked by decreased bone mineral density (BMD).
Reduced BMD is observed in patients with urolithiasis (kidney stones), irrespective of urinary calcium levels (hypercalciuria or normocalciuria).
Bisphosphonates are established treatments for osteoporosis, primarily by inhibiting bone resorption.

Purpose:

To investigate the efficacy of bisphosphonates in preventing the recurrence of urolithiasis.
To determine the effect of bisphosphonates on urinary calcium excretion and stone formation indices.
To explore the potential dual benefit of bisphosphonates in managing both osteoporosis and calcium-based kidney stones.

Summary:

Bisphosphonates demonstrated a significant reduction in urinary calcium excretion in urolithiasis patients.
The study showed that bisphosphonates prevented urinary stone formation in a long-term bed rest model.
Alendronate (ALN), a type of bisphosphonate, was found to improve osteoporosis and decrease the risk of calcium stone formation.

Impact:

Bisphosphonates may offer a dual therapeutic benefit, addressing both osteoporosis and the risk of calcium urolithiasis.
The findings suggest that bisphosphonates could reduce calcium stone formation by improving bone metabolism and directly impacting urinary parameters.
This research opens avenues for utilizing osteoporosis medications in the prevention of recurrent kidney stones.