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Abnormal ECG patterns in chronic post-war PTSD patients: a pilot study.

Habibolah Khazaie1, Mohammad Reza Saidi, Amir Ali Sepehry

  • 1Sleep Research Center, Department of Psychiatry, Farabi Hospital, Kermanshah University of Medical Sciences (KUMS), PO Box 6719851151, Kermanshah, Iran. hakhazaie@gmail.com

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Patients with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) exhibit significantly higher rates of electrocardiogram (ECG) abnormalities compared to healthy individuals, indicating increased cardiovascular risk.

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Area of Science:

  • Cardiology
  • Psychiatry
  • Autonomic Nervous System Research

Background:

  • Post-traumatic stress disorder (PTSD) is linked to heightened sympathetic nervous system activity.
  • Individuals with PTSD demonstrate a predisposition to electrocardiogram (ECG) abnormalities, conduction defects, and cerebrovascular events.

Purpose of the Study:

  • To investigate the prevalence of ECG abnormalities in patients diagnosed with chronic post-war PTSD.
  • To compare ECG findings between PTSD patients, major depressive disorder (MDD) patients, and healthy controls.

Main Methods:

  • A pilot study involving 30 patients with chronic post-war PTSD, 24 with MDD, and 20 healthy controls.
  • Participants underwent a standard 12-lead ECG assessment after completing the Structured Clinical Interview for the DSM (SCID).

Main Results:

  • ECG abnormalities were found in 66.7% of PTSD patients and 70.8% of MDD patients, versus 28.6% in healthy controls.
  • Adjusted analyses revealed PTSD and MDD patients were significantly more likely to have ECG abnormalities (OR=12.7 for PTSD, OR=14.9 for MDD).

Conclusions:

  • Elevated rates of ECG abnormalities were observed in both PTSD and MDD patient groups compared to healthy controls.
  • These findings highlight a potential increased cardiovascular risk in patients with PTSD and MDD, with implications for medical management.