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Related Experiment Video

Updated: May 28, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Complement in cancer and cancer immunotherapy.

Martin Kolev¹, Laurence Towner, Rossen Donev

¹Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.

Archivum Immunologiae Et Therapiae Experimentalis

|October 1, 2011

Summary

Cancer immunotherapies leverage the immune system to fight malignancies. This review explores the complement system's role in tumor growth and antibody-based cancer treatments, discussing strategies to overcome tumor defenses.

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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

Area of Science:

Oncology
Immunology
Biochemistry

Background:

Growing interest in biological and immune-based therapies for cancer.
Advances in understanding the immune system-tumor crosstalk.
Immunotherapy offers high specificity and reduced toxicity compared to traditional treatments.

Purpose of the Study:

To review the role of the complement system in tumor progression.
To examine the function of the complement system in antibody-based cancer immunotherapy.
To discuss strategies for overcoming complement-mediated tumor resistance.

Main Methods:

Literature review focusing on complement system and cancer.
Analysis of tumor overexpression of complement regulators.
Exploration of therapeutic strategies against complement evasion.

Main Results:

The complement system significantly influences tumor growth and immune evasion.
Tumors often overexpress complement regulators to escape immune attack.
Strategies to inhibit complement regulators can enhance immunotherapy efficacy.

Conclusions:

The complement system is a critical target for cancer immunotherapy.
Overcoming complement-mediated resistance is key to improving treatment outcomes.
Further research into complement-targeted agents holds promise for novel cancer therapies.