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Related Experiment Videos

Cyclosporin A in atopic dermatitis.

J S Ross1, R D Camp

  • 1St John's Hospital, London, U.K.

The British Journal of Dermatology
|June 1, 1990
PubMed
Summary

Oral cyclosporin A (CyA) effectively treats severe atopic dermatitis in most patients. Long-term use requires careful monitoring for side effects like increased creatinine levels.

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Area of Science:

  • Immunodermatology
  • Pharmacology

Background:

  • Oral cyclosporin A (CyA) is used for inflammatory skin conditions.
  • Only psoriasis has demonstrated efficacy in controlled trials.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral cyclosporin A for severe atopic dermatitis.

Main Methods:

  • Thirteen patients with severe atopic dermatitis received oral CyA.
  • Treatment duration was up to 31 months.

Main Results:

  • Ten patients showed a good response, one moderate, and two slight.
  • Two patients discontinued CyA due to elevated creatinine after over two years.

Conclusions:

  • Cyclosporin A is a potential treatment for severe, therapy-resistant atopic dermatitis.
  • Close monitoring of side effects and dose adjustments are essential.